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novartis cancer pill

THE CANCER PILL

Dr. Brian Druker of Oregon Health Sciences University was searching for a compound that could block the enzyme that caused chronic myelogenous leukemia or CML for short.  He recently stabilized a compound he had noticed to suppress the enzyme, that compound, STI 571, was recently being run through clinical trials to verify its action.  He has been working at Oregon Health Sciences University on the pill, but the distribution and trials of the drugs are being run through Novartis Pharmaceuticals.  The outcome of this revolutionary cancer treatment could help many people currently suffering from this condition if its trials prove it completely safe.  So far in the clinical trials it has had a one hundred percent success rate curing thirty-one out of thirty-one patients so far tested.  The Leukemia Society of America, the National Cancer Institute, Novartis Pharmaceuticals, and the Oregon Cancer Center fund Dr. Drukers research and studies.  So far the research has only been tested on CML leukemia, but there is doubt it will work on other forms because it was specifically formulated for the suppression of the enzyme responsible for CML leukemia and its specific chromosome, the Philadelphia chromosome.  Out of all the forms of leukemia CML accounts for about 1/7 of the cases only affecting about one to two people per one hundred thousand, most above the age of 50.  It causes an enormous increase in the white blood cell count, sometimes as great as twelve fold or from the average 10,000 to 120,000.  In most cases you die about one to three years after diagnosis.
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OCD

OCD
(Obsessive Compulsive Disorder)
OCD is a very common disorder affecting almost everyone in the world, some being affected much more than others. First of all I will give a brief definition of OCD. Obsessive Compulsive Disorder causes the brain to get stuck on one particular urge or thought that can't easily be let go. People with OCD often call it a case of, "mental hiccups that won't go away." Everyone has this condition in one way or another. For instance, a man might go into a bathroom and flush the toilet with his foot so he won't have to touch the handle that others have handled after handling themselves. Someone with a worse case in the same situation might go in the bathroom, use toilet paper to lower or raise the lid, flush with foot before use, flush with foot after use, use paper towel to turn water on, wash his hands for a few minutes to get off all possible germs, and use more paper towels to open door following up with hand sanitizer. OCD usually involves having obsessions and compulsions although having one or the other is not uncommon. First is the obsession, which is thoughts, images, and impulses that occur over and over again that make the person feel out of control.
Obsessions
     Obsessions are thoughts, images, or impulses that occur over and over again and feel out of your control. The person does not want to have these ideas, finds them disturbing and intrusive, and usually recognizes that they don't really make sense. People with OCD may worry excessively about dirt and germs and be obsessed with the idea that they are contaminated or may contaminate others. Or they may have obsessive fears of having inadvertently harmed someone else (perhaps while pulling the car out of the driveway), even though they usually know this is not realistic. Obsessions are accompanied by uncomfortable feelings, such as fear, disgust, doubt, or a sensation that things have to be done in a way that is "just so."
Compulsions
     People with OCD typically try to make their obsessions go away by performing compulsions. Compulsions are acts the person performs over and over again, often according to certain "rules." People with an obsession about contamination may wash constantly to the point that their hands become raw and inflamed. A person may repeatedly check that she has turned off the stove or iron because of an obsessive fear of burning the house down. She may have to count certain objects over and over because of an obsession about losing them. Unlike compulsive drinking or gambling, OCD compulsions do not give the person pleasure. Rather, the rituals are performed to obtain relief from the discomfort caused by the obsessions.
     The following chart was taken from www.ocd.com and shows typical obsessions and the compulsions that follow.
Table 1. Typical OCD Symptoms
Common Obsessions:     Common Compulsions:
Contamination fears of germs, dirt, etc.     Washing
Imagining having harmed self or others     Repeating
Imagining losing control of aggressive urges     Checking
Intrusive sexual thoughts or urges     Touching
Excessive religious or moral doubt     Counting
Forbidden thoughts     Ordering/arranging
A need to have things "just so"     Hoarding or saving
A need to tell, ask, confess     Praying

     OCD can start at any time from preschool age to adulthood. One third to one half of adults with OCD report that it started during childhood. Unfortunately, OCD often goes unrecognized. Studies have also found that it takes an average of 17 years from the time OCD begins for people to obtain appropriate treatment. There is no single, proven cause of OCD. Research suggests that OCD involves problems in communication between the front part of the brain (the orbital cortex) and deeper structures (the basal ganglia). These brain structures use the chemical messenger serotonin. It is believed that insufficient levels of serotonin are prominently involved in OCD. Drugs that increase the brain concentration of serotonin often help improve OCD symptoms. Although it seems clear that reduced levels of serotonin play a role in OCD, there is no laboratory test for OCD. Rather, the diagnosis is made based on an assessment of the person's symptoms. When OCD starts suddenly in childhood in association with strap throat, an autoimmune mechanism may be involved, and treatment with an antibiotic may prove helpful. Research shows that the serotonin reuptake inhibitors (SRIs) are effective treatments for OCD. ... more

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